It was namely in Shusha where Armenians started assaulting and murdering Azerbaijanis, trying to reduce their numbers as much as possible and expel them from the lands they had inhabited for centuries. That could be the only reason for continuous attacks on the Azerbaijani part of the town combined with blocking main roads and sieging Azerbaijani settlements. Avoiding direct assaults on Azerbaijani villages, Armenians resorted to isolating the Azerbaijani population in Shusha.
Dashnak militants closed the road between Agdam and Shusha near Askeran. One of the longest blockages of Shusha, it commenced in August 1905 and continued into 1906. Communications with the town severed, the population could face famine and total extermination.
Closing the main road from Askeran fortress and all cart roads between Agdam and Shusha resulted in the town dwellers alongside Muslim (Azerbaijani) population of Shusha, Jabrayil, and Zangezur uyezds being denied the opportunity to procure food and living essentials 
Zangezur Uyezd was one of the areas in Yelizavetpol Governorate where Dashnaks intended to create "a one-piece land for Armenian nation" by terrorizing Azerbaijanis. During the second half of 1905, Armenians committed localized attacks on Azerbaijanis, robbed them and shoot at the roads. They razed several villages and murdered, wounded or took hostage their dwellers 
. On 26 and 27 September 1905, Armenian militants attacked 10 Azerbaijani villages in Zangezur and burned them to ash. Some villagers fled for their life and hid in the woods 
The Zangezur massacre acquired unprecedented scale in summer 1906; According to archive sources, Armenian militants slaughtered many Muslim (Azerbaijanis) civilians in Zangezur Uyezd on 2-24 August, wiping out the following villages: Shabadin, Okhchu, Atkiz, Pirdavdan, Karkhana, Katar, Khalaj, Injevar, Chullu, Zurul, Farajan, Emazli, Guman, Kollu, Sanalu, Metnazar, Kalaboyni, Megrulu, Mollanu, Tanzavar, Agvanlu, Khashtan, Firidunbeg Kishlagi 
Armenian atrocities in Zangezur are evidenced by recollections of Russian commissioned officer V.Vadin, which were published in 1907.
Written after his visit to Karabakh, they are dripping with sympathy for Armenians and disdain for Azerbaijanis. These recollections, nevertheless, contain an interesting episode the author fills with an obvious admiration of Dashnaks, or, as he brands them, "saviors of Armenian nation". Vadin had a guide, a Dashnak named Sako, who confessed to the former that he had burned 12 villages in Zangezur, murdering and tormenting the local Azerbaijani population. Branding them "subhumans", the cutthroat said about Muslims he loathed: "robbery is viewed as heroism, bloody vengeance a debt, and science and education only a name." 
The Zangezur massacre was one of the greatest tragedies in the history of 1905-1906 Armenian-Azerbaijani conflict. Despite the lack of accurate statistics and scarce accounts, the available sources still provide a sufficiently clear picture of scales of terror Armenians committed against the Azerbaijani population of Zangezur Uyezd in 1906.
The late 1905 and early 1906 saw bloody skirmishes ongoing in Jevanshir Uyezd. This region had a special importance for Dashnaks, as after the August 1905 Shusha massacre their militant organization's center was deployed in its mountainous Armenian villages. It stockpiled weapons and ammo and accommodated armed Armenian workers from Baku, who were arriving in big groups via Yelizavetpol, bypassing the direct road to Jevanshir Uyezd through Yevlakh.
Dashnak groups rampaging in in Jevanshir Uyezd were reporting to Amazasp Servastyan. According to Captain N.M. Fleginsky, Chief of Uyezd Police Department, stationed in Uyezd's Armenian villages and across the entire Karabakh were groups of well-armed and trained foot and horse-mounted militants, who "can arrive in designated locations at the whistle of their leader, the notorious Amazasp. Horse-mounted mobs patrol the area, setting up pickets in vicinity of Tatar (Azerbaijani) villages."
Large-scale clashes commenced when Servastyan-led detachment assaulted Damirlar village and set it on fire. In response, Azerbaijanis razed Armenian villages of Chayly, Upper Chayly, and Lower Seysulan 
The Karabakh events, inter alia, resulted in Armenians taking over the lands abandoned by Azerbaijani people. That was one of Dashnak's primary objectives they sought to accomplish at the time of 1905-1906 interethnic conflict: to spread discord between Armenians and Muslims of the South Caucasus and clear lands to accommodate Armenian settlers from the Ottoman Empire and Iran. In October 1906, in particular, some 30 Armenian families moved from Garar village of Zangezur Uyezd to Muslim (Azerbaijani) lands in Umutlu village (Jeanshir Uyezd) and, settling in, started ploughing and over agricultural activities. Another group of Armenian families from Garar (some 100 households) also moved to Umutlu and settled there 
The first months of 1906 saw a new round of bloodshed in Shusha Uyezd. The most complete account of the dire situation Azerbaijan was facing under siege is provided by the cable sent by Shusha dweller A. Vazirov to the editorial boards of Kaspi and Hayat:
"Shusha's Muslims (Azerbaijanis) are in a terrible situation; it has been a month and a half since Armenian bandits severed all lines of communication. The delivery of important supplies has been suspended, and one can obtain dough, sugar, and other essentials only by mail. Famine is everywhere. There have been several deaths as a result... Armenian militants vandalize the entire uyezd. A gang set on fire several houses in Malybeklu village; they also attacked a headquarters in Khankendi and stabbed to death local Muslim (Azerbaijani) children and women, with Cossacks watching; it then set on fire Najaf Gulu agha's and Doctor Mehmandarov's manors. The town is cut off Muslim (Azerbaijan) centers. Despite all the complaints and telegrams to General Governor and Viceroy, there is still no outcome in favor of Muslims (Azerbaijanis). Armenians are acting boldly in the town, frequently firing at Tatar (Azerbaijani) quarters without any cause." 
O. Apresyan, a native of Karabakh who evidenced the Shusha massacre, admitted that Armenians had decided to wipe out all Azerbaijanis in Khankendi and committed the atrocity at night. Almost 20 years had passed since the night of Khankendi massacre, but Apresyan was still under the impression of atrocities his compatriots committed there.